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Ayesha De Souza

 

Dr Ayesha De Souza
BSc, ARCS, PhD, DIC
Senior Research Fellow
Cardiac Proteomics
Cardiac Arrhythmias Group
Division of Cardiac & Vascular Sciences
St. George’s University of London
Cranmer Terrace
London SW17 0RE
Telephone: +44 (0)208 725 3482
Fax: +44 (0)208 725 2812
 
Biography
Dr Ayesha De Souza obtained her BSc Hons in Biochemistry and PhD in Cardiac Medicine from Imperial College London. During her PhD, she undertook research in a cardiac electrophysiology laboratory investigating excitation-contraction coupling in models of left ventricular hypertrophy at the National Heart and Lung Institute, Imperial College London. On completion of her PhD, she remained at Imperial College London and undertook a post-doctoral research position in the transplant immunology group at the Heart Science Centre, Harefield Hospital. She published a seminal paper describing the use of laser microdissection in combination with proteomics in human heart, which she was invited to give a keynote lecture on at Inserm, Paris in 2008. Furthermore, she identified, for the first time, the association of heat shock protein 27 with freedom from graft vasculopathy following human cardiac transplantation.
In 2006, Dr De Souza was appointed to her current position, Senior Research Fellow, with the aim of setting up her own proteomics laboratory. Her successful and productive cardiac proteomics laboratory undertakes basic research as part of the cardiac arrhythmias group under the direction of Professor John Camm. Her research focuses on elucidating the molecular mechanisms underlying atrial fibrillation and heart failure utilizing both proteomic and metabolomic technologies. She has established successful research collaborations with several European, Canadian and Australian research groups. Dr De Souza has presented her work at national and international meetings including the AHA, ESC, HRS and BCS. She is currently a member of the American Heart Association.
Dr De Souza has also been invited to Chair and organize three proteomic/biomarker meetings in conjunction with EuroSciCon.
Research Interests
Atrial fibrillation
Heart failure
Proteomics
Metabolomics
Biomarkers of cardiovascular disease
Selected Publications
Metabolic profiling provides insights into right and left atrial profibrillatory remodelling in heart failure. De Souza AI, Cardin S, Chung Y-L, Wait R, Camm AJ, Nattel S. Circulation 2009; 120:S711-S712
Proteomic and metabolomic analysis of failing human left atrium reveals insights into the underlying mechanisms of atrial fibrillation. De Souza AI, Patel N, Wait R, Chung Y-L, Bajpai A, dos Remedios C, Camm AJ. European Heart Journal 2009; 30 (suppl. 1): 950
Proteomic analyses reveal evolving protein expression changes during atrial profibrillatory remodelling in congestive heart failure. De Souza AI, Cardin S, Wait R, Patel N, Camm AJ, Nattel S. European Heart Journal 2009; 30 (suppl. 1): 61
Remodelling of atrial metabolism in heart failure: insights from metabolomic profiling. De Souza AI, Cardin S, Patel N, Chung Y-L, Wait R, Camm AJ, Nattel S. European Heart Journal 2009; 30 (suppl. 1): 951
Insights into molecular basis of atrial profibrillatory remodelling in congestive heart failure using proteomics. De Souza AI, Cardin S, Wait R, Patel N, Shiroshita-Takeshita A, Camm AJ, Nattel S. Heart Rhythm 2008; Issue 5S (Vol. 5): P04-7
Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoportein E-deficient mice. Mayr M, Zampetaki A, Sidibe A, Mayr U, Yin X, De Souza AI, Chung Y-L, Madhu B, Quax PH, Hu Y, Griffiths JR, Xu Q. 2008; 102: 1046-1056
Dose-related effect of statins on atrial fibrillation after cardiac surgery. Kourliouros A, De Souza AI, Robert N, Marciniakm, Tsiouris A, Valencia O, Camm AJ, Jahangiri M. Annals of Thoracic Surgery 2008; 85: 1515-1520
Combined metabolomic and proteomic analysis of human atrial fibrillation. Mayr M, Yusuf S, Weir G, Chung Y-L, Mayr U, Yin X, Ladroue C, Madhu B, Roberts N, De Souza AI, Fredericks S, Stubbs M, Griffiths JR, Jahangiri M, Xu Q, Camm AJ. Journal of the American College of Cardiology 2008; 51: 585-594.
Proteomic analysis provides insights into molecular mechanisms of atrial profibrillatory remodelling in congestive heart failure. De Souza AI, Cardin S, Wait R, Patel N, Shiroshita-Takeshita A, Camm AJ, Nattel S. Circulation 2007; Suppl II (Vol. 116, No. 16): 1234
Proteomics and Laser Microdissection. McGregor E, De Souza AI. In Methods in Molecular Medicine - Transplantation Immunology (Hornick and Rose (eds.) Humana Press. 2006; 13: 291-304
Heat shock protein 27 is associated with freedom from graft vasculopathy following human cardiac transplantation. De Souza AI, Wait, R, Mitchell A, Banner NR, Dunn ML, Rose ML. Circulation Research 2005; 97: 192-198
Sequential expression of three known protective genes in cardiac biopsies following transplantation. De Souza AI, Felkin LE, McCormack AM, Holder A, Barton PJ, Banner NR, Rose ML. Transplantation 2005; 79: 584-590
Preparation of human heart for laser microdissection and proteomics. De Souza AI, McGregor E, Dunn ML, Rose ML. Proteomics 2004; 4: 578-586
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